Compazine Pharmacology, Pharmacokinetics, Studies, Metabolism - Prochlorperazine

Compazine Pharmacology, Pharmacokinetics, Studies, Metabolism - Prochlorperazine

CLINICAL PHARMACOLOGY

Prochlorperazine is a propylpiperazine derivative of phenothiazine. Like other phenothiazines, it exerts an antiemetic effect through a depressant action on the chemoreceptor trigger zone. It also has a clinically useful, antipsychotic effect. Following intramuscular administration of prochlorperazine edisylate, the drug has an onset of action within ten to twenty minutes and a duration of action of three to four hours.