A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Prepidil Warnings, Precautions, Pregnancy, Nursing, Abuse - Dinoprostone cervical
Prepidil Warnings, Precautions, Pregnancy, Nursing, Abuse - Dinoprostone cervical
WARNINGS
FOR HOSPITAL USE ONLY
Dinoprostone, as with other potent oxytocic agents, should
be used only with strict adherence to recommended dosages. Dinoprostone should
be administered by physicians in a hospital that can provide immediate intensive
care and acute surgical facilities.
PRECAUTIONS
1.General Precautions:
During use, uterine activity, fetal status, and character of
the cervix (dilation and effacement) should be carefully monitored either by
auscultation or electronic fetal monitoring to detect possible evidence of undesired
responses, eg, hypertonus, sustained uterine contractility, or fetal distress.
In cases where there is a history of hypertonic uterine contractility or tetanic
uterine contractions, it is recommended that uterine activity and the state
of the fetus should be continuously monitored. The possibility of uterine rupture
should be borne in mind when high-tone myometrial contractions are sustained.
Feto-pelvic relationships should be carefully evaluated before
use of PREPIDIL Gel (see CONTRAINDICATIONS).
Caution should be exercised in administration of PREPIDIL Gel
in patients with:
· asthma
or history of asthma
· glaucoma
or raised intraocular pressure
Caution should be taken so as not to administer PREPIDIL Gel
above the level of the internal os. Careful vaginal examination will reveal
the degree of effacement which will regulate the size of the shielded endocervical
catheter to be used. That is, the 20mm endocervical catheter should be used
if no effacement is present, and the 10mm catheter should be used if the cervix
is 50% effaced. Placement of PREPIDIL Gel into the extra-amniotic space has
been associated with uterine hyperstimulation.
As PREPIDIL Gel is extensively metabolized in the lung, liver,
and kidney, and the major route of elimination is the kidney, PREPIDIL Gel should
be used with caution in patients with renal and hepatic dysfunction.
2.Patients With Ruptured Membranes:
Caution should be exercised in the administration of PREPIDIL
Gel in patients with ruptured membranes. The safety of use of PREPIDIL Gel in
these patients has not been determined.
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