A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Taxol Online, Description, Chemistry, Ingredients - Paclitaxel
Taxol Online, Description, Chemistry, Ingredients - Paclitaxel
DESCRIPTION
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WARNING
TAXOL® (paclitaxel) Injection should be
administered under the supervision of a physician
experienced in the use of cancer
chemotherapeutic agents. Appropriate management of complications
is possible only when adequate diagnostic
and treatment
facilities are readily available.
Anaphylaxis and severe hypersensitivity
reactions characterized by dyspnea
and hypotension
requiring treatment,
angioedema,
and generalized urticaria have occurred in 2% of patients
receiving TAXOL in clinical
trials. Fatal reactions have occurred in patients despite
premedication. All patients should be pretreated with corticosteroids,
diphenhydramine, and H2antagonists. (See DOSAGE
AND ADMINISTRATION section.) Patients who experience
severe hypersensitivity
reactions to TAXOL should not be rechallenged with the drug.
TAXOL therapy
should not be given to patients with solid tumors who have
baseline neutrophil
counts of less than 1,500 cells/mm3 and should
not be given to patients with AIDS- related Kaposi’s sarcoma
if the baseline
neutrophil
count is less
than 1000 cells/mm3. In order
to monitor the
occurrence of bone
marrow suppression,
primarily neutropenia, which may be severe and result in
infection,
it is recommended that frequent peripheral
blood cell
counts be performed on all patients receiving TAXOL.
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TAXOL® (paclitaxel) Injection
is a clear colorless to slightly yellow
viscous solution. It
is supplied as a nonaqueous solution
intended for dilution
with a suitable parenteral fluid prior to intravenous
infusion. TAXOL is available in 30 mg
(5 mL), 100 mg (16.7 mL),
and 300 mg (50 mL) multidose
vials. Each mL of sterile nonpyrogenic solution
contains 6 mg paclitaxel,
527 mg of purified Cremophor®
EL* (polyoxyethylated castor oil) and 49.7% (v/v) dehydrated alcohol,
USP.
Paclitaxel is a natural
product with antitumor
activity. TAXOL is obtained via a semi-synthetic process
from Taxus baccata. The chemical
name for paclitaxel is 5ß, 20-Epoxy-1,2a,
4,7ß, 10ß, 13a-hexahydroxytax-11-en-9-one
4,10-diacetate 2- benzoate
13-ester with (2R, 3 S)- N-benzoyl-3-phenylisoserine.
Paclitaxel is a white
to off- white crystalline
powder with the empirical
formula C47H51NO14 and a molecular
weight of 853.9. It is highly lipophilic, insoluble
in water, and melts at around 216-217°C.
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