A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Xenical Online, Description, Chemistry, Ingredients - Orlistat
Xenical Online, Description, Chemistry, Ingredients - Orlistat
DESCRIPTION
XENICAL (orlistat) is a lipase inhibitor
for obesity management
that acts by inhibiting the absorption of dietary
fats.
Orlistat is (S)-2-formylamino-4-methyl-pentanoic acid (S)-1-[[(2S,
3S)-3-hexyl-4-oxo-2-oxetanyl] methyl]-dodecyl ester. Its empirical
formula is C29H53NO5, and its
molecular weight is 495.7. It is a single diastereomeric molecule that
contains four chiral centers, with a negative optical rotation in ethanol
at 529 nm. The structure is:
Orlistat is a white to
off-white crystalline powder. Orlistat is practically insoluble
in water, freely soluble in chloroform, and very soluble
in methanol and ethanol.
Orlistat has no pKa
within the physiological
pH range.
XENICAL is available for oral administration
in dark-blue, hard-gelatin capsules, with light-blue imprinting.
Each capsule contains
120 mg of the active ingredient,
orlistat. The capsules also contain the inactive ingredients microcrystalline
cellulose, sodium starch
glycolate, sodium lauryl
sulfate, povidone, and talc. Each capsule shell
contains gelatin, titanium
dioxide, and FD&C Blue No.1, with printing of pharmaceutical
glaze NF, titanium
dioxide, and FD&C Blue No.1 aluminum
lake.
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