A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Optivar Online, Description, Chemistry, Ingredients - Azelastine hydrochloride
Optivar Online, Description, Chemistry, Ingredients - Azelastine hydrochloride
OPTIVAR® azelastine hydrochloride ophthalmic solution,
0.05%
DESCRIPTION
OPTIVAR® (azelastine hydrochloride ophthalmic solution)
0.05% is a sterile ophthalmic solution containing azelastine hydrochloride,
a relatively selective H1-receptor antagonist for topical administration
to the eyes. Azelastine hydrochloride is a white crystalline powder with a molecular
weight of 418.37. Azelastine hydrochloride is sparingly soluble in water, methanol
and propylene glycol, and slightly soluble in ethanol, octanol and glycerine.
Azelastine hydrochloride is a racemic mixture with a melting point of 225°C.
The chemical name for azelastine hydrochloride is (±)-1-(2H)-phthalazinone, 4-[(4-chlorophenyl)
methyl] –2-(hexahydro–1 -methyl-1H-azepin- 4-yl)-, monohydrochloride Empirical
chemical structure: C22H24ClN3O•HCl
Each mL of OPTIVAR® contains: Active: 0.5 mg azelastine
hydrochloride, equivalent to 0.457 mg of azelastine base; Preservative:
0.125 mg benzalkonium chloride; Inactives: disodium edetate dihydrate,
hydroxypropylmethylcellulose, sorbitol solution, sodium hydroxide and water
for injection. It has a pH of approximately 5.0 to 6.5 and an osmolality of
approximately 271 to 312 mOsmol/L.
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