A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Aygestin Side Effects, and Drug Interactions - Norethindrone
Aygestin Side Effects, and Drug Interactions - Norethindrone
SIDE EFFECTS
The following adverse reactions have been observed in women taking progestins:
Breakthrough bleeding.
Spotting.
Change in menstrual flow.
Amenorrhea.
Edema.
Changes in weight (decreases, increases).
Changes in cervical erosion and cervical secretions.
Cholestatic jaundice.
Rash (allergic) with and without pruritus.
Melasma or chloasma.
Mental depression.
Acne.
Breast enlargement/tenderness.
Headache/migraine.
Urticaria.
Abnormalities of liver tests (i.e., AST, ALT, Bilirubin).
Mood swings.
Nausea.
Insomnia.
Anaphylactic/anaphylactoid reactions.
Progestins may alter the result of pregnanediol determinations. The following
laboratory results may be altered by the concomitant use of estrogens with progestins:
Hepatic function.
Coagulation tests increase in prothrombin, factors VII, VIII, IX, and X.
Increase in PBI, BEI, and a decrease in T 3 uptake.
Reduced response to metyrapone test.
A statistically significant association has been demonstrated between use of
estrogen-progestogen combination drugs and the following serious adverse reactions:
thrombophlebitis, pulmonary embolism, and cerebral thrombosis and embolism.
For this reason, patients on progestogen therapy should be carefully observed.
Although available evidence is suggestive of an association, such a relationship
has been neither confirmed nor refuted for the following serious adverse reactions:
Neuro-ocular lesions, e.g., retinal thrombosis and optic neuritis.
The following adverse reactions have been observed in patients receiving estrogen-progestogen
combination drugs:
- Rise in blood pressure in susceptible individuals.
- Premenstrual-like syndrome.
- Changes in libido.
- Changes in appetite.
- Cystitis-like syndrome.
- Headache.
- Nervousness.
- Dizziness.
- Fatigue.
- Backache.
- Hirsutism.
- Loss of scalp hair.
- Erythema multiforme.
- Erythema nodosum.
- Hemorrhagic eruption.
- Itching.
In view of these observations, patients on progestogen therapy should be carefully
observed.
DRUG INTERACTIONS
No Information Provided.
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