A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Ortho-Novum Side Effects, and Drug Interactions - Norethindrone and Ethinyl Estradiol
Ortho-Novum Side Effects, and Drug Interactions - Norethindrone and Ethinyl Estradiol
SIDE EFFECTS
An increased risk of the
following serious adverse reactions has been associated with the
use of oral contraceptives
(see WARNINGS).
- Thrombophlebitis
- Arterial thromboembolism
- Pulmonary embolism
- Myocardial infarction
- Cerebral hemorrhage
- Cerebral thrombosis
- Hypertension
- Gallbladder disease
- Hepatic adenomas, carcinomas or benign
liver tumors
There is evidence
of an association
between the following conditions and the use of oral
contraceptives, although additional confirmatory studies are needed:
- Mesenteric thrombosis
- Retinal thrombosis
The following adverse reactions have been reported in patients
receiving oral contraceptives and are believed to be drug-related:
- Nausea
- Vomiting
- Gastrointestinal symptoms (such as abdominal
cramps and bloating)
- Breakthrough bleeding
- Spotting
- Change in menstrual flow
- Amenorrhea
- Temporary infertility after discontinuation of treatment
- Edema
- Melasma which may persist
- Breast changes; tenderness, enlargement, secretion
- Change in weight
(increase or decrease)
- Change in cervical
erosion and secretion
- Diminution in lactation
when given immediately postpartum
- Cholestatic jaundice
- Migraine
- Rash (allergic)
- Mental depression
- Reduced tolerance
to carbohydrates
- Vaginal candidiasis
- Change in corneal curvature
(steepening)
- Intolerance to contact
lenses
The following adverse reactions have been reported in users of
oral contraceptives and the association
has been neither confirmed nor refuted:
- Pre-menstrual syndrome
- Cataracts
- Changes in appetite
- Cystitis-like syndrome
- Headache
- Nervousness
- Dizziness
- Hirsutism
- Loss of scalp hair
- Erythema multiforme
- Erythema nodosum
- Hemorrhagic eruption
- Vaginitis
- Porphyria
- Impaired renal function
- Hemolytic uremic
syndrome
- Budd Chiari syndrome
- Acne
- Changes in libido
- Colitis
DRUG INTERACTIONS
Reduced efficacy and increased incidence
of breakthrough bleeding
and menstrual irregularities have been associated with concomitant
use of rifampin. A similar association
though less marked, has been suggested with barbiturates, phenylbutazone,
phenytoin sodium,
and possibly with griseofulvin, ampicillin and tetracyclines.78
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