A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cardene Overdose, Contraindications and Information - Nicardipine
Cardene Overdose, Contraindications and Information - Nicardipine
OVERDOSE
Overdosage with a 600 mg
single dose (15 to 30 times
normal clinical dose)
has been reported. Marked hypotension
(blood pressure unobtainable)
and bradycardia
(heart rate 20 bpm in normal
sinus rhythm) occurred,
along with drowsiness,
confusion and slurred
speech. Supportive treatment
with a vasopressor
resulted in gradual improvement with normal
vital signs approximately
9 hours post treatment.
Based on the results obtained in laboratory
animals, overdosage may cause systemic
hypotension, bradycardia
(following initial tachycardia)
and progressive
atrioventricular
conduction block.
Reversible hepatic function
abnormalities and sporadic
focal hepatic
necrosis were noted
in some animal species receiving very large doses of nicardipine.
For treatment
of overdose standard
measures (for example, evacuation of gastric
contents, elevation
of extremities, attention
to circulating fluid volume
and urine output) including
monitoring of cardiac
and respiratory functions should be implemented. The patient
should be positioned so as to avoid cerebral anoxia. Frequent blood
pressure determinations
are essential. Vasopressors are clinically indicated for patients
exhibiting profound hypotension. Intravenous calcium
gluconate may help reverse the effects of calcium
entry blockade.
CONTRAINDICATIONS
Nicardipine HCl is contraindicated in patients with hypersensitivity
to the drug.
Because proof of the effect
of nicardipine HCl
is secondary to reduced
afterload, the drug is
also contraindicated in patients with advanced aortic stenosis.
Reduction of diastolic
pressure in these patients
may worsen rather than improve myocardial
oxygen balance.
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