A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cardene Indications, Dosage, Storage, Stability - Nicardipine
Cardene Indications, Dosage, Storage, Stability - Nicardipine
INDICATIONS
I. Stable Angina
Nicardipine HCl is indicated for the management of patients with
chronic stable angina
(effort-associated angina). Nicardipine HCl may be used alone or
in combination with beta-blockers.
II. Hypertension
Nicardipine HCl is indicated for the treatment
of hypertension. Nicardipine HCl may be used alone or in combination
with other anti hypertensive
drugs. In administering nicardipine
it is important to be aware of the relatively large peak to trough
differences in blood pressure
effect. (See DOSAGE AND ADMINISTRATION
.)
DOSAGE AND ADMINISTRATION
Angina
The dose should be individually
titrated for each patient
beginning with 20 mg to 40
mg three times daily. Doses
in the range of 20-40
mg three times a day have
been shown to be effective. At
least three days should be allowed before increasing the nicardipine
HCl dose to ensure achievement
of steady state plasma
drug concentrations.
Concomitant Use with Other Antihypertensive Agents
Sublingual NTG may be taken as required to abort
acute anginal attacks
during nicardipine
HCl therapy.
Prophylactic Nitrate Therapy - nicardipine
HCl may be safely coadministered with short- and long-acting nitrates.
Beta-blockers - nicardipine
HCl may be safely coadministered with beta-blockers. (See DRUG
INTERACTIONS.)
Hypertension
The dose of nicardipine
HCl should be individually adjusted according to the blood
pressure response
beginning with 20 mg three
times daily. The effective doses in clinical
trials have ranged from 20 mg
to 40 mg three times daily. The maximum
blood pressure
lowering effect occurs
approximately 1-2 hours after dosing. To assess the adequacy
of blood pressure
response, the blood pressure
should be measured at trough
(8 hours after dosing). Because of the prominent peak effects of
nicardipine, blood pressure
should be measured 1-2 hours after dosing, particularly during initiation
of therapy. (See PRECAUTIONS,
Blood Pressure, INDICATIONS
AND USAGE and CLINICAL PHARMACOLOGY,
Effects in Hypertension.) At
least three days should be allowed before increasing the nicardipine
HCl dose to ensure achievement
of steady state plasma
drug concentrations.
Concomitant use with other Antihypertensive Agents
Diuretics - Nicardipine HCl may be safely coadministered
with thiazide diuretics.
Beta-blockers - Nicardipine HCl may be safely coadministered
with beta-blockers (See DRUG INTERACTIONS.)
Special Patient Populations
Renal Insufficiency - Although there is no
evidence that nicardipine
HCl impairs renal function,
careful dose titration
beginning with 20 mg TID is advised. (See PRECAUTIONS.)
Hepatic Insufficiency - Nicardipine HCl should be
administered cautiously in,patients with severely impaired hepatic
function. A suggested starting dose
of 20 mg twice a day is advised
with individual titration based on clinical
findings maintaining the twice a day schedule. (See PRECAUTIONS.)
Congestive Heart Failure - Caution is advised when
titrating nicardipine HCl dosage
in patients with congestive heart
failure. (See WARNINGS).
HOW SUPPLIED
Store bottles at room
temperature and
dispense in light
resistant containers.
Store blister packages
at room temperature
and protect from excessive humidity and light. To protect from light,
product should remain
in manufacturer's package until consumed.
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