A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cardene Online, Description, Chemistry, Ingredients - Nicardipine
Cardene Online, Description, Chemistry, Ingredients - Nicardipine
DESCRIPTION
Nicardipine HCl capsules for oral
administration
each contain 20 mg or 30 mg
of nicardipine hydrochloride.
Nicardipine HCl is a calcium
ion flux inhibitor
(slow channel blocker
or calcium channel
blocker).
Nicardipine hydrochloride
is a dihydropyridine structure
with the IUPAC (International Union of Pure and Applied Chemistry)
chemical name 2- (benzyl-methyl
amino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
monohydrochloride.
Nicardipine hydrochloride
is a greenish-yellow, odorless, crystalline powder that melts at
about 169°C. It is freely soluble
in chloroform, methanol, and glacial
acetic acid,
sparingly soluble in
anhydrous ethanol,
slightly soluble in
n-butanol, water, 0.01 M potassium
dihydrogen phosphate, acetone, and dioxane, very slightly soluble
in ethyl acetate, and
practically insoluble in benzene, ether
and hexane. It has a molecular weight
of 515.99.
Nicardipine HCl is available in hard gelatin
capsules containing 20 mg or 30 mg nicardipine
hydrochloride with magnesium
stearate and pregelatinized
starch as the inactive ingredients. the 20 mg strength
is provided in opaque white-white capsules with a brilliant blue
band while the 30 mg capsules
are opaque light
blue-powder blue with a brilliant
blue band. The colorants used
in the 20 mg capsules are titanium
dioxide, D&C Red #7 Calcium Lake and FD&C Blue #1 and the 30 mg
capsules use titanium dioxide,
FD&C Blue #1, D&C Yellow #10 Aluminum Lake, D&C Red #7 Calcium
Lake and FD&C Blue #2.
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