A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cortisporin Side Effects, and Drug Interactions - Hydrocortisone; Neomycin; Polymyxin B
Cortisporin Side Effects, and Drug Interactions - Hydrocortisone; Neomycin; Polymyxin B
SIDE EFFECTS
Neomycin occasionally causes skin
sensitization. Ototoxicity and nephrotoxicity have also been reported
(see WARNINGS). Adverse
reactions have occurred with topical
use of antibiotic
combinations including neomycin and polymyxin
B. Exact incidence
figures are not available since no denominator of treated patients
is available. The reaction
occurring most often is allergic
sensitization. In one clinical
study, using a 20% neomycin patch, neomycin-induced allergic
skin reactions occurred
in two of 2175 (0.09%) individuals in the general population.1
In another study, the incidence
was found to be approximately 1%.2
The following local adverse
reactions have been reported with topical corticosteroids, especially
under occlusive dressings:
burning, itching, irritation, dryness, folliculitis, hypertrichosis,
acneiform eruptions,
hypopigmentation, perioral
dermatitis, allergic
contact dermatitis,
maceration of the skin, secondary infection, skin
atrophy, striae, and miliaria.
Cream: When steroid
preparations are used for long periods of time
in intertriginous areas or over extensive body areas, with or without
occlusive non-permeable dressings, striae may occur; also there
exists the possibility of systemic
side effects when steroid
preparations are used over large areas or for a long period
of time.
Otic Solution: Stinging and burning have been reported
when this product has
gained access to the middle ear.
DRUG INTERACTIONS
No information provided.
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