A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Naprosyn Online, Description, Chemistry, Ingredients - Naproxen
Naprosyn Online, Description, Chemistry, Ingredients - Naproxen
EC- NAPROSYN ® ( naproxen)
Delayed- Release Tablets
NAPROSYN ® ( naproxen)
Tablets
ANAPROX / ANAPROX® ® DS
( naproxen sodium) Tablets
NAPROSYN ® ( naproxen)
Suspension
DESCRIPTION
Naproxen is a member of the arylacetic acid group of nonsteroidal anti- inflammatory
drugs.
The chemical names for naproxen and naproxen sodium are ( S)- 6- methoxy- a
- methyl- 2- naphthaleneacetic acid and ( S)- 6- methoxy- a - methyl- 2- naphthaleneacetic
acid, sodium salt, respectively.
Naproxen is an odorless, white to off- white crystalline substance. It is lipid-
soluble, practically insoluble in water at low pH and freely soluble in water
at high pH. The octanol/ water partition coefficient of naproxen at pH 7.4 is
1.6 to 1.8. Naproxen sodium is a white to creamy white, crystalline solid, freely
soluble in water at neutral pH.
NAPROSYN ( naproxen) Tablets contain 250 mg, 375 mg or 500 mg of naproxen and
croscarmellose sodium, iron oxides, povidone and magnesium stearate.
EC- NAPROSYN ( naproxen) Delayed- Release Tablets are enteric- coated tablets
containing 375 mg or 500 mg of naproxen and croscarmellose sodium, povidone
and magnesium stearate. The enteric coating dispersion contains methacrylic
acid copolymer, talc, triethyl citrate, sodium hydroxide and purified water.
The dispersion may also contain simethicone emulsion. The dissolution of this
enteric- coated naproxen tablet is pH dependent with rapid dissolution above
pH 6. There is no dissolution below pH 4.
Each ANAPROX 275 mg and ANAPROX DS 550 mg tablet contains naproxen sodium,
the active ingredient, with magnesium stearate, microcrystalline cellulose,
povidone and talc. The coating suspension for the ANAPROX 275 mg tablet may
contain hydroxypropyl methylcellulose 2910, Opaspray K- 1- 4210A, polyethylene
glycol 8000 or Opadry YS- 1- 4215. The coating suspension for the ANAPROX DS
550 mg tablet may contain hydroxypropyl methylcellulose 2910, Opaspray K- 1-
4227, polyethylene glycol 8000 or Opadry YS- 1- 4216.
NAPROSYN ( naproxen) Suspension for oral administration contains 125 mg/ 5
mL of naproxen in a vehicle containing sucrose, magnesium aluminum silicate,
sorbitol solution and sodium chloride ( 30 mg/ 5 mL, 1.5 mEq), methylparaben,
fumaric acid, FD& C Yellow No. 6, imitation pineapple flavor, imitation
orange flavor and purified water. The pH of the suspension ranges from 2.2 to
3.7.
top
