A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Relafen Overdose, Contraindications and Information - Nabumetone
Relafen Overdose, Contraindications and Information - Nabumetone
OVERDOSE
Since only one case of
nabumetone overdose
has been reported, the experience is limited. If acute
overdose occurs, it
is recommended that the stomach
be emptied by vomiting
or lavage and general
supportive measures be instituted, as necessary. In
addition, the use of activated charcoal, up to 60 grams, may effectively
reduce nabumetone absorption.
Coadministration of nabumetone with charcoal
to man has resulted in an
80% decrease in maximum
plasma concentrations
of the active metabolite.
The one overdose occurred
in a 17-year-old female
patient who had a history
of abdominal pain
and was hospitalized for increased abdominal
pain following ingestion
of 30 nabumetone tablets (15 grams total). Stools were negative
for occult blood
and there was no fall in
serum hemoglobin
concentration. The patient
had no other symptoms. She was given an H2-receptor antagonist
and discharged from the hospital
without sequelae.
CONTRAINDICATIONS
Nabumetone is contraindicated in patients who have previously exhibited
hypersensitivity to it.
Nabumetone is contraindicated in patients in whom nabumetone, aspirin
or other NSAIDs induce asthma, urticaria
or other allergic-type reactions. Fatal asthmatic reactions have
been reported in such patients receiving NSAIDs.
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