A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Trexall Online, Description, Chemistry, Ingredients - Methotrexate
Trexall Online, Description, Chemistry, Ingredients - Methotrexate
DESCRIPTION
Methotrexate (formerly Amethopterin) is an antimetabolite
used in the treatment of certain neoplastic diseases, severe psoriasis,
and adult rheumatoid arthritis.
Chemically methotrexate
is N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic
acid.
Molecular weight: 454.45 C20H22N8O5 and the structural
formula is:
Methotrexate tablets, for oral administration, are available in 5 mg, 7.5 mg,
10 mg and 15 mg strengths.
Each tablet contains methotrexate sodium in an amount equivalent to the labeled amount
of methotrexate, and contains the following inactive ingredients: anhydrous lactose,
crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose,
polyethylene glycol, polysorbate 80, pregelatinized starch, sodium carbonate monohydrate,
talc and titanium dioxide.
The 5 mg also contains: D&C yellow no. 10 aluminum lake, FD&C blue no. 1 aluminum lake
and FD&C yellow no. 6 aluminum lake.
The 7.5 mg also contains: FD&C blue no.1 aluminum lake.
The 10 mg also contains: FD&C red no. 40 aluminum lake.
The 15 mg also contains: FD&C blue no. 2 aluminum lake and FD&C red no. 40 aluminum lake.
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