A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Remeron Overdose, Contraindications and Information - Mirtazapine
Remeron Overdose, Contraindications and Information - Mirtazapine
OVERDOSE
Human Experience
There is very limited experience with REMERON® (mirtazapine)
Tablets overdose. In premarketing clinical studies, there were eight reports
of REMERON® overdose alone or in combination with other pharmacological
agents. The only drug overdose death reported while taking REMERON®
was in combination with amitriptyline and chlorprothixene in a non-US
clinical study. Based on plasma levels, the REMERON® dose taken
was 30–45 mg, while plasma levels of amitriptyline and chlorprothixene were
found to be at toxic levels. All other premarketing overdose cases resulted
in full recovery. Signs and symptoms reported in association with overdose included
disorientation, drowsiness, impaired memory, and tachycardia. There were no
reports of ECG abnormalities, coma or convulsions following overdose with REMERON®
alone.
Overdose Management
Treatment should consist of those general measures employed
in the management of overdose with any drug effective in the treatment of major
depressive disorder. Ensure an adequate airway, oxygenation, and ventilation.
Monitor cardiac rhythm and vital signs. General supportive and symptomatic measures
are also recommended. Induction of emesis is not recommended. Gastric lavage
with a large-bore orogastric tube with appropriate airway protection, if needed,
may be indicated if performed soon after ingestion, or in symptomatic patients.
Activated charcoal should be administered. There is no experience
with the use of forced diuresis, dialysis, hemoperfusion or exchange transfusion
in the treatment of mirtazapine overdosage. No specific antidotes for mirtazapine
are known.
In managing overdosage, consider the possibility of multiple-drug
involvement. The physician should consider contacting a poison control center
for additional information on the treatment of any overdose. Telephone numbers
for certified poison control centers are listed in the Physicians’ Desk Reference
(PDR).
CONTRAINDICATIONS
REMERON® (mirtazapine) Tablets are contraindicated
in patients with a known hypersensitivity to mirtazapine.
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