A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Minocin Side Effects, and Drug Interactions - Minocycline
Minocin Side Effects, and Drug Interactions - Minocycline
SIDE EFFECTS
Due to oral minocycline's
virtually complete absorption,
side effects to the lower
bowel, particularly diarrhea,
have been infrequent. The following adverse reactions have been
observed in patients receiving tetracyclines.
Gastrointestinal: Anorexia, nausea,
vomiting, diarrhea,
glossitis, dysphagia,
enterocolitis,
pancreatitis, inflammatory
lesions (with monilial overgrowth) in the anogenital
region, and increases in liver enzymes. Rarely, hepatitis
and liver failure
have been reported. Rare instances of esophagitis
and esophageal ulcerations
have been reported in patients taking the tetracycline-class antibiotics
in capsule and tablet
form. Most of these patients took the medication
immediately before going to bed
(see DOSAGE AND ADMINISTRATION).
Skin: Maculopapular and erythematous rashes. Exfoliative
dermatitis has been reported but is uncommon. Fixed drug
eruptions have been rarely reported. Lesions occurring on the glans
penis have caused balanitis.
Erythema multiforme and rarely Stevens-Johnson syndrome
have been reported. Photosensitivity is discussed above (see WARNINGS).
Pigmentation of the skin
and mucous membranes
has been reported.
Renal toxicity: Elevations in BUN
have been reported and are apparently dose
related (see WARNINGS).
Reversible acute renal
failure has been rarely
reported.
Hypersensitivity reactions: Urticaria, angioneurotic
edema, polyarthralgia, anaphylaxis,
anaphylactoid purpura,
pericarditis, exacerbation
of systemic lupus
erythematosus and rarely pulmonary
infiltrates with eosinophilia have been reported. A transient
lupus-like syndrome
has also been reported.
Blood: Hemolytic anemia,
thrombocytopenia,
neutropenia, and eosinophilia
have been reported.
Central nervous
system: Bulging fontanels in infants and benign intracranial
hypertension (Pseudotumor
cerebri) in adults (see PRECAUTIONS,
General) have been reported. Headache has also been reported.
Other: When given over prolonged periods, tetracyclines
have been reported to produce brown-black microscopic discoloration
of the thyroid glands.
Very rare cases of abnormal
thyroid function
have been reported.
Decreased hearing has
been rarely reported in patients on minocycline hydrochloride.
Tooth discoloration in children less than 8 years of age
(see WARNINGS) and also,
rarely, in adults have been reported.
DRUG INTERACTIONS
Because tetracyclines have been shown to depress plasma
prothrombin activity, patients who are on anticoagulant
therapy may require
downward adjustment of their anticoagulant
dosage.
Since bacteriostatic
drugs may interfere with the bactericidal
action of penicillin, it is advisable to avoid giving tetracycline-class
drugs in conjunction with penicillin.
Absorption of tetracyclines is impaired by antacids containing
aluminum, calcium or magnesium,
and iron-containing preparations.
The concurrent use of tetracycline
and methoxyflurane
has been reported to result in fatal
renal toxicity.
Concurrent use of tetracyclines with oral
contraceptives may render oral contraceptives less effective.
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