A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Toprol Xl Overdose, Contraindications and Information - Metoprolol Succinate
Toprol Xl Overdose, Contraindications and Information - Metoprolol Succinate
OVERDOSE
Acute Toxicity
There have been a few reports of overdosage with extended release
metoprolol succinate and no specific
overdosage information was obtained with this drug, with the exception
of animal toxicology
data. However, since extended release metoprolol succinate
contains the same active moiety, metoprolol, as conventional metoprolol
tablets (metoprolol tartrate
salt), the recommendations on overdosage for metoprolol conventional
tablets are applicable to Toprol-XL.
Signs and Symptoms
Potential signs and symptoms associated with overdosage with metoprolol
are bradycardia, hypotension, bronchospasm, and cardiac
failure.
Treatment
There is no specific
antidote.
In general, patients with acute
or recent myocardial
infarction may be
more hemodynamically unstable than other patients and should be
treated accordingly. On the basis
of the pharmacologic actions of metoprolol tartrate, the following
general measures should be employed.
Elimination of the Drug: Gastric lavage
should be performed.
Bradycardia: Atropine should be administered. If
there is no response
to vagal blockade, isoproterenol
should be administered cautiously.
Hypotension: A vasopressor
should be administered, e.g., levarterenol or dopamine.
Bronchospasm: A beta2-stimulating agent
and/or a theophylline
derivative should
be administered.
Cardiac Failure: A digitalis
glycoside and diuretics
should be administered. In
shock resulting from inadequate
cardiac contractility,
administration of dobutamine, isoproterenol or glucagon
may be considered.
CONTRAINDICATIONS
Hypertension and Angina: Extended release
metoprolol succinate is contraindicated in sinus
bradycardia, heart block
greater than first degree, cardiogenic
shock, and overt cardiac
failure (see WARNINGS.)
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