A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Toprol Xl Indications, Dosage, Storage, Stability - Metoprolol Succinate
Toprol Xl Indications, Dosage, Storage, Stability - Metoprolol Succinate
INDICATIONS
Hypertension: Extended release
metoprolol succinate
tablets are indicated for the treatment
of hypertension. They may be used alone or in combination with other
antihypertensive
agents.
Angina Pectoris: Extended release
metoprolol succinate tablets are indicated in the long-term treatment
of angina pectoris.
DOSAGE AND ADMINISTRATION
Metoprolol succinate
is an extended release
tablet intended for once-a-day
administration. When switching from immediate
release metoprolol tablet
to extended release
metoprolol succinate, the same total daily dose
of extended release
metoprolol succinate
should be used.
As with immediate
release metoprolol,
dosages of extended release
metoprolol succinate should be individualized and titration
may be needed in some patients.
Extended release metoprolol
succinate tablets
are scored and can be divided; however, the whole or half tablet
should be swallowed whole and not chewed or crushed.
Hypertension
The usual initial dosage
is 50 to 100 mg daily in
a single dose, whether used alone or added to a diuretic. The dosage
may be increased at weekly (or longer) intervals until optimum
blood pressure
reduction is achieved.
In general, the maximum
effect of any given dosage
level will be apparent
after 1 week of therapy. Dosages above 400 mg
per day have not been studied.
Angina Pectoris
The dosage to extended
release metoprolol succinate
should be individualized. The usual initial
dosage is 100 mg
daily, given in a single dose. The dosage may be gradually increased
at weekly intervals until optimum
clinical response has
been obtained or there is a pronounced slowing of the heart
rate. Dosages above 400 mg
per day have not been studied.
If treatment is to
be discontinued, the dosage
should be reduced gradually over a period
of 1-2 weeks (see WARNINGS.)
HOW SUPPLIED
Toprol-XL 50 mg tablets contain 47.5 mg of metoprolol succinate
equivalent to 50 mg of metoprolol tartrate. They are white, biconvex,
round and film-coated. They
are engraved "A mo" on one side
and scored on the other.
Toprol-XL 100 mg tablets contain 95 mg of metoprolol succinate
equivalent to 100 mg of metoprolol tartrate. They are white, biconvex,
round and film-coated. They are engraved "A ms" on one side
and scored on the other.
The Toprol-XL 200 mg tablets contain 190 mg of metoprolol succinate equivalent
to 200 mg of metoprolol tartrate. They are white, biconvex, oval and film-coated.
They are engraved "A my" and scored on one side.
Store at controlled room
temperature 15-30°C
(59-86°F).
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