A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Toprol Xl Online, Description, Chemistry, Ingredients - Metoprolol Succinate
Toprol Xl Online, Description, Chemistry, Ingredients - Metoprolol Succinate
DESCRIPTION
Toprol-XL, metoprolol succinate, is a beta1-selective (cardioselective)
adrenoceptor blocking agent,
for oral administration, available
as extended release tablets. Toprol-XL has been formulated to provide
a controlled and predictable release
of metoprolol for once daily administration. The tablets comprise a multiple
unit system
containing metoprolol succinate in a multitude of controlled release
pellets. Each pellet acts as
a separate drug delivery unit
and is designed to deliver
metoprolol continuously over the dosage
interval. The tablets contain 47.5 mg, 95 mg and 190 mg of metoprolol
succinate equivalent to
50, 100 and 200 mg of metoprolol tartrate, USP, respectively. Its chemical
name is (±) 1-(isopropylamino)-3-[p-(2-methoxyethyl)
phenoxy]-2-propanol succinate (2:1) (salt).
Metoprolol succinate is
a white crystalline
powder with a molecular weight
of 652.8. It is freely soluble
in water; soluble in methanol;
sparingly soluble in ethanol; slightly soluble
in dichloromethane and 2- propanol; practically insoluble
in ethyl-acetate, acetone, diethylether and heptane. Inactive ingredients:
silicon dioxide, cellulose
compounds, sodium stearyl fumarate,
polyethylene glycol,
titanium dioxide, paraffin.
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