A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Ritalin Pharmacology, Pharmacokinetics, Studies, Metabolism - Methylphenidate Hcl
Ritalin Pharmacology, Pharmacokinetics, Studies, Metabolism - Methylphenidate Hcl
CLINICAL PHARMACOLOGY
Ritalin is a mild central nervous system stimulant.
The mode of action in man is not completely understood, but
Ritalin presumably activates the brain stem arousal system and cortex to produce
its stimulant effect.
There is neither specific evidence which clearly establishes
the mechanism whereby Ritalin produces its mental and behavioral effects in
children, nor conclusive evidence regarding how these effects relate to the
condition of the central nervous system.
Ritalin in the SR tablets is more slowly but as extensively
absorbed as in the regular tablets. Relative bioavailability of the SR tablet
compared to the Ritalin tablet, measured by the urinary excretion of Ritalin
major metabolite (a-phenyl-2-piperidine acetic acid)
was 105% (49%-168%) in children and 101% (85%-152%) in adults. The time to peak
rate in children was 4.7 hours (1.3-8.2 hours) for the SR tablets and 1.9 hours
(0.3-4.4 hours) for the tablets. An average of 67% of SR tablet dose was excreted
in children as compared to 86% in adults.
In a clinical study involving adult subjects who received SR
tablets, plasma concentrations of Ritalin’s major metabolite appeared to be
greater in females than in males. No gender differences were observed for Ritalin
plasma concentration in the same subjects.
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