A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Dolophine Side Effects, and Drug Interactions - Methadone
Dolophine Side Effects, and Drug Interactions - Methadone
SIDE EFFECTS
THE MAJOR HAZARDS OF METHADONE AS
OF OTHER NARCOTIC ANALGESICS, ARE RESPIRATORY DEPRESSION AND TO
A LESSER DEGREE, CIRCULATORY DEPRESSION. RESPIRATORY ARREST SHOCK,
AND CARDIAC ARREST HAVE OCCURRED.
The most frequently observed adverse reactions include lightheadedness,
dizziness, sedation,
nausea, vomiting,
and sweating. These effects seem to be more prominent in ambulatory
patients and in those who are not suffering severe chronic
pain. In such
individuals, lower doses are advisable. Some adverse reactions may
be alleviated in the ambulatory patient
if he lies down.
Other adverse reactions include the following:
Central Nervous System-Euphoria, dysphoria,
weakness, headache, insomnia,
agitation, disorientation,
and visual disturbances.
Gastrointestinal- Dr.
mouth, anorexia,
constipation and
biliary tract spasm.
Cardiovascular- Flushing of the face, bradycardia,
palpitations, faintness, and syncope.
Genitourinary- Urinary retention
or hesitancy, antidiuretic effect, and reduced libido
and/or potency.
Allergic- Pruritus, urticaria,
other skin rashes, edema,
and, rarely, hemorrhagic
urticaria.
Hematologic- Reversible thrombocytopenia
has been described in a narcotics addict
with chronic hepatitis.
DRUG INTERACTIONS
Interaction with Pentazocine
Patients who are addicted to heroin
or who are on the methadone maintenance program may experience
withdrawal symptoms
when given pentazocine.
Interaction with Rifampin
The concurrent administration
of rifampin may possibly
reduce the blood concentration
of methadone. The mechanism
by which rifampin may
decrease blood concentrations of methadone is not fully understood
although enhanced microsomal drug-metabolized enzymes may influence
drug disposition.
Interaction with Monoamine Oxidase (MAO) Inhibitors
Therapeutic doses of meperidine have precipitated severe reactions
in patients concurrently receiving monoamine
oxidase inhibitors or
those who have received such
agents within 14 days. Similar reactions thus far have not been
reported with methadone; but if the use of methadone is necessary
in such patients, a sensitivity
test should be performed
in which repeated small incremental doses are administered over
the course of several hours while the patient's condition
and vital signs are under
careful observation.
Interaction with Other Central-Nervous-Systern Depressants
Methadone should be used with caution and in reduced dosage
in patients who are concurrently receiving other narcotic
analgesics, general anesthetics, phenothiazines, other tranquilizers,
sedative-hypnotics, tricyclic antidepressants, and other CNS
depressants (including alcohol). Respiratory depression, hypotension,
and profound sedation
or coma may result.
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