A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Demerol Side Effects, and Drug Interactions - Meperidine
Demerol Side Effects, and Drug Interactions - Meperidine
SIDE EFFECTS
The major hazards of meperidine, as with other narcotic
analgesics, are respiratory
depression and
to a lesser degree, circulatory
depression; respiratory arrest, shock, and cardiac
arrest have occurred.
The most frequently observed adverse reactions include lightheadedness,
dizziness, sedation,
nausea, vomiting,
and sweating. These effects seem to be more prominent in ambulatory
patients and in those who are not experiencing severe pain. In
such individuals, lower
dosage are advisable.
Some adverse reactions in ambulatory patients may be alleviated
if the patients lies down.
Other adverse reactions include:
Nervous System: Euphoria, dysphoria,
weakness, headache,
agitation, tremor, uncoordinated muscle
movements, severe convulsions, transient
hallucinations and disorientation, visual
disturbances. Inadvertent injection
about a nerve trunk
may result in sensory-motor paralysis
which is usually, though not always, transitory.
Gastrointestinal: Dry mouth, constipation,
biliary tract
spasm.
Cardiovascular: Flushing of the face, tachycardia,
bradycardia, palpitation, hypotension
(see WARNINGS), syncope,
phlebitis following
intravenous injection.
Genitourinary: Urinary retention.
Allergic: Pruritus, urticaria,
other skin rashes, wheal
and flare over the vein
with intravenous
injection.
Other: Pain at injection
site; local tissue
irritation and
induration following subcutaneous
injection, particularly
when repeated; antidiuretic effect.
DRUG INTERACTIONS
Interaction with Other Central Nervous System Depressants:
MEPERIDINE SHOULD BE USED WITH GREAT CAUTION AND IN REDUCED DOSAGE
IN PATIENTS WHO ARE CONCURRENTLY RECEIVING OTHER NARCOTIC ANALGESICS,
GENERAL ANESTHETICS, PHENOTHIAZINES, OTHER TRANQUILIZERS (SEE DOSAGE
AND ADMINISTRATION), SEDATIVE-HYPNOTICS (INCLUDING BARBITURATES),
TRICYCLIC ANTIDEPRESSANTS AND OTHER CNS
DEPRESSANTS (INCLUDING ALCOHOL). RESPIRATORY DEPRESSION, HYPOTENSION,
AND PROFOUND SEDATION OR
COMA MAY RESULT.
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