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Antivert Pharmacology, Pharmacokinetics, Studies, Metabolism - Meclizine

Antivert Pharmacology, Pharmacokinetics, Studies, Metabolism - Meclizine

CLINICAL PHARMACOLOGY

Meclizine hydrochloride is an antihistamine which shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum.

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