A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Claritin Overdose, Contraindications and Information - Loratadine
Claritin Overdose, Contraindications and Information - Loratadine
OVERDOSE
In adults, somnolence, tachycardia, and headache
have been reported with overdoses greater than 10 mg
with the tablet formulation
(40 to 180 mg). Extrapyramidal signs and palpitations have been
reported in children with overdoses of greater than 10 mg
of loratadine syrup.
In the event of overdosage,
general symptomatic
and supportive measures should be instituted promptly and maintained
for as long as necessary.
Treatment of overdosage would reasonably consist of emesis
(ipecac syrup), except in patients with impaired consciousness,
followed by the administration
of activated charcoal
to absorb any remaining
drug. If vomiting is
unsuccessful, or contraindicated, gastric
lavage should be performed
with normal saline. Saline cathartics may also be of value
for rapid dilution
of bowel contents. Loratadine
is not eliminated by hemodialysis. It is not known if loratadine
is eliminated by peritoneal
dialysis.
No deaths occurred at oral
doses up to 5000 mg/kg in rats and mice (greater than 2400 and 1200
times, respectively, the maximum
recommended human daily
oral dose
on a mg/m2 basis). Single oral
doses of loratadine
showed no effects in rats, mice, and monkeys at doses as high as
10 times the maximum
recommended human daily
oral dose
on a mg/m2 basis.
CONTRAINDICATIONS
Loratadine is contraindicated in patients who are hypersensitive
to this medication
or to any of its ingredients.
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