A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lomotil Side Effects, and Drug Interactions - Diphenoxylate / Atropine
Lomotil Side Effects, and Drug Interactions - Diphenoxylate / Atropine
SIDE EFFECTS
At therapeutic doses, the following have been reported;
they are listed in decreasing order
of severity, but not of frequency:
Nervous System: numbness
of extremities, euphoria,
depression, malaise/lethargy, confusion,
sedation/drowsiness, dizziness,
restlessness, headache.
Allergic: anaphylaxis,
angioneurotic edema, urticaria,
swelling of the gums, pruritus.
Gastrointestinal System: toxic
megacolon, paralytic
ileus, pancreatitis, vomiting,
nausea, anorexia,
abdominal discomfort.
The following atropine sulfate
effects are listed in decreasing order of severity, but not of frequency:
hyperthermia, tachycardia,
urinary retention, flushing,
dryness of the skin and
mucosus membranes. There effects may occur, especially in children.
THIS MEDICATION SHOULD BE KEPT IN A CHILD-RESISTANT CONTAINER AND
OUT OF THE REACH OF CHILDREN SINCE AN OVERDOSAGE MAY RESULT IN SEVERE
RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO
PERMANENT BRAIN DAMAGE OR
DEATH.
Drug Abuse and Dependence
Controlled Substance: Atropine sulfate
is classified as a Schedule V controlled substance
by federal regulation. Diphenoxylate HCl is chemically related to
the narcotic analgesic
meperidine.
Drug Abuse And Dependence: In
doses used for the treatment
of diarrhea, whether acute
or chronic, diphenoxylate
has not produced addiction.
Diphenoxylate HCl is devoid of morphine-like subjective
effects at therapeutic doses. At
high doses it exhibits codeine-like subjective
effects. The dose which produces antidiarrheal
action is widely separated
from the dose which causes
central nervous
system effects. The insolubility
of diphenoxylate HCl in commonly available aqueous
media precludes intravenous
self-administration. A dose
of 100 to 300 mg/day, which is equivalent
to 40 to 120 tablets, administered to humans for 40 to 70 days,
produced opiate withdrawal
symptoms. Since addition
to diphenoxylate HCl is possible at high doses, the recommended
dosage should not be exceeded.
DRUG INTERACTIONS
Known drug interactions
include barbiturates, tranquilizers and alcohol. Atropine sulfate
may interact with MAO inhibitors
(see WARNINGS.)
In studies with male rats
diphenoxylate HCl was found to inhibit the hepatic microsomal enzyme
system at a dose
of 2 mg/kg/day. Therefore, diphenoxylate has the potential
to prolong the biological
half-lives of drugs for which the rate
of elimination is
dependent on the microsomal drug
metabolizing enzyme system.
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