A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Librax Indications, Dosage, Storage, Stability - Chlordiazepoxide and Clidinium
Librax Indications, Dosage, Storage, Stability - Chlordiazepoxide and Clidinium
INDICATIONS
Based on a review of this drug
by the National Academy of Sciences – National Research Council
and/or other information, FDA has classified the indications as
follows:
“Possibly” effective: as adjunctive therapy
in the treatment of
peptic ulcer and in the treatment
of the irritable bowel
syndrome (irritable
colon, spastic colon, mucous
colitis) and acute enterocolitis.
Final classification
of the less-than-effective indications requires further investigation.
DOSAGE AND ADMINISTRATION
Because of the varied individual responses to tranquilizers and
anticholinergics, the optimum
dosage of Librax varies
with the diagnosis
and response of the
individual patient. The dosage,
therefore, should be individualized for maximum
beneficial effects. The usual maintenance dose
is 1 or 2 capsules, 3 or 4 times a day administered before meals
and at bedtime.
HOW SUPPLIED
Librax is available in green
capsules, each containing 5 mg
chlordiazepoxide hydrochloride (Librium) and 2.5 mg
clidinium bromide (Quarzan):
- bottles of 100 (NDC 0140-0007-01)
- bottles of 500 (NDC 0140-0007-14).
REFERENCES
1. Schallek W, et al. Arch Int Pharmacodyn.
1964; 149: 467-483.
2. Himwich HE, et al. J Neuropsych. Aug 1962;
3 (Suppl. 1): S15-S26.
3. Morillo. A, et. al. Psychopharmacologia.
1962; 3 (No. 5): 386-394.
4. MacLean PD. Psychosomatic Afed. Sept 1955;
l7: 355-366.
5. Morgan CT. Physiological Psychology. 3rd
ed. New York McGraw-Hill; 1965.
6. Randall LO, et al. J Pharm 4 Exper Therap.
June 1960; 129: 163-171.
7. Miller LC and Tainter MC. Proc Soc Exp Biol
E Med. 1944; 57: 261.
8. Zbinden G, et al. Toxicology and Applied Pharmacology.
Nov 1961; 3.619-637.
9, Data on file, Hoffmann-La Roche Inc., Nutley,
N. J.
10. Bibliography and References available on request
from Roche Laboratories.
11. Rickels K, et al. Med Timhs. Mar 1965;
93: 238-245.
12. Tobin JM, et al. J Amer Med Assoc. Nov
1960; 174: 1242-1249.
13. Jenner FA, et al. J Ment Sci. May 1961;
107: 575-582.
14. Robinson RCV. Dis Nerv System. Mar 1960;
21: 43-45.
15. Rose JT. Amer J Psychiat. Mar 1964; 120:
899-900.
16. Hines LR. Corr Therap Res. June 1960;
2: 227-236.
17. Gibbs FA, Gibbs EL. J Neuropsych. Aug
1962; 3 (Suppl 1): S73-S78.
18. Kaelbling R, et al. J Amer Med Assoc.
Dec 1960; 174: 1863-1865.
19. Cacioppo J, et al. Amer J Psychiat. May
1961; 117: 1040-1041.
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