A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lupron Side Effects, and Drug Interactions - Leuprolide acetate
Lupron Side Effects, and Drug Interactions - Leuprolide acetate
SIDE EFFECTS
Clinical Trials:
Potential exacerbation of signs and symptoms during the first
few weeks of treatment (See PRECAUTIONS section)
is a concern in patients with rapidly advancing central precocious puberty.
In two studies of children with central precocious puberty,
in 2% or more of the patients receiving the drug, the following adverse reactions
were reported to have a possible or probable relationship to drug as ascribed
by the treating physician. Reactions considered not drug related are excluded.
|
|
Number of Patients N = 395 (Percent)
|
|
Body as a Whole
|
|
|
General Pain
|
7(2)
|
|
Integumentary System
|
|
|
Acne/Seborrhea
|
7(2)
|
|
Injection Site Reactions
|
|
|
Including Abscess
|
21(5)
|
|
Rash Including
|
|
|
Erythema Multiforme
|
8(2)
|
|
Urogenital System
|
|
|
Vaginitis/Bleeding/Discharge
|
7(2)
|
In those same studies, the following adverse reactions were
reported in less than 2% of the patients.
Body as a Whole - Body Odor, Fever, Headache, Infection;
Cardiovascular System - Syncope, Vasodilation; Digestive System -
Dysphagia, Gingivitis, Nausea/Vomiting; Endocrine System - Accelerated
Sexual Maturity; Metabolic and Nutritional Disorders-Peripheral Edema,
Weight Gain; Nervous System-Nervousness, Personality Disorder, Somnolence,
Emotional Lability;
Respiratory System - Epistaxis; Integumentary System
- Alopecia, Skin Striae; Urogenital System - Cervix Disorder, Gynecomastia/Breast
Disorders, Urinary Incontinence.
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