A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Prevacid Online, Description, Chemistry, Ingredients - Lansoprazole
Prevacid Online, Description, Chemistry, Ingredients - Lansoprazole
DESCRIPTION
The active ingredient
in lansoprazole
delayed-release capsules is a substituted benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluroethoxy)-2-pyridyl]methyl]sulfinyl]
benzimidazole, a compound
that inhibits gastric
acid secretion. Its empirical
formula is C16H14F3N3O2S
with a molecular weight
of 369.37.
Lansoprazole is a white
to brownish-white odorless crystalline
powder which melts with decomposition
at approximately 166°C. Lansoprazole is freely soluble
in dimethylformamide; soluble
in methanol; sparingly soluble in ethanol; slightly soluble
in ethyl acetate, dichloromethane
and acetonitrile; very slightly soluble
in ether; and practically insoluble in hexane and water.
Lansoprazole is stable
when exposed to light
for up to two months. The compound degrades in aqueous
solution, the rate of degradation
increasing with decreasing pH. At
25°C the t½ is approximately 0.5 hour at pH
5.0 and approximately 18 hours at pH
7.0.
Prevacid is supplied in delayed-release capsules for oral
administration. The delayed-release capsules contain the active ingredient,
lansoprazole, in the form of
enteric-coated granules
and are available in two dosage strengths: 15 mg and 30 mg of lansoprazole
per capsule. Each delayed-release
capsule contains enteric-coated
granules consisting of lansoprazole, hydroxypropyl cellulose, low substituted
hydroxypropyl cellulose, colloidal silicon
dioxide, magnesium carbonate, methacrylic acid
copolymer, starch, talc, sugar
sphere, sucrose, polyethylene
glycol, polysorbate 80, and titanium
dioxide. Components of the gelatin
capsule include gelatin, titanium
dioxide, D&C red no. 28, FD&C
blue no. 1, FD&C green
no. 3 (Prevacid 15 mg capsules only), and FD&C red
no. 40.
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