A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Toradol Overdose, Contraindications and Information - Ketorolac
Toradol Overdose, Contraindications and Information - Ketorolac
OVERDOSE
In controlled overdosage, daily doses of 360 mg
of ketorolac tromethamine IV/IMgiven for five days (3 times the
highest recommended dose), caused abdominal pain
and peptic ulcers which
healed after discontinuation of doses. Metabolic acidosis
has been reported following intentional overdosage.
Dialysis does not significantly clear ketorolac tromethamine
from the blood stream.
CONTRAINDICATIONS
(see also BOXED WARNING)
- Ketorolac tromethamine
is CONTRAINDICATED in patients with active peptic ulcer disease,
in patients with recent gastrointestinal
bleeding or perforation,
and in patients with a history
of peptic ulcer
disease or gastrointestinal
bleeding.
- Ketorolac tromethamine
is CONTRAINDICATED in patients with advanced renal impairment,
or in patients at risk
of renal failure
due to volume depletion (see WARNINGS
for correction
of volume depletion).
- Ketorolac tromethamine
is CONTRAINDICATED in labor
and delivery because,
through its prostaglandin
synthesis inhibitory
effect, it may adversely affect fetal
circulation and
inhibit uterine contraindications,
thus increasing the risk
of uterine hemorrhage.
- The use of ketorolac tromethamine
is CONTRAINDICATED in nursing
mothers because of the potential
adverse effects of prostaglandin-inhibiting drugs on neonates.
- Ketorolac tromethamine
is CONTRAINDICATED in patients with previously demonstrated hypersensitivity
to ketorolac tromethamine, or allergic
manifestations to aspirin
or other non-steroidal anti-inflammatory
drugs (NSAIDs).
- Ketorolac tromethamine
is CONTRAINDICATED as prophylactic
analgesic before any major surgery
is critical because
of the increased risk
of bleeding.
- Ketorolac tromethamine
inhibits platelet
function and is,
therefore, CONTRAINDICATED in patients with suspected or confirmed
cerebrovascular bleeding, hemorrhagic
diathesis, incomplete hemostasis
and those at high risk of bleeding
(see WARNINGS and PRECAUTIONS).
- Ketorolac tromethamine
is CONTRAINDICATED in patients currently receiving ASA or NSAIDs
because of the cumulative
risks of inducing serious NSAID related adverse events.
- Ketorolac tromethamine
IV/IM is CONTRAINDICATED for neuraxial (epidural or intrathecal)
administration
due to its alcohol
content.
- The concomitant
use of ketorolac tromethamine
and probenecid
is CONTRAINDICATED.
Ophthalmic Solution: Acular (ketorolac tromethamine) ophthalmic
solution is contraindicated in patients while wearing soft
contact lenses and in
patients with previously demonstrated hypersensitivity
to any of the ingredients in the formulation.
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