Slow K Side Effects, and Drug Interactions - Potassium Chloride Extended-release

Slow K Side Effects, and Drug Interactions - Potassium Chloride Extended-release

SIDE EFFECTS

One of the most severe adverse effects is hyperkalemia (see CONTRAINDICATIONS, WARNINGS, AND OVERDOSAGE). Gastrointestinal bleeding and ulceration have been reported in patients treated with Micro-K^® Extencaps^® (see CONTRAINDICATIONS and WARNINGS). In addition to gastrointestinal bleeding and ulceration, perforation and obstruction have been reported in patients treated with other solid KCl dosage forms, and may occur with Micro-K^® Extencaps^®.

The most common adverse reactions to the oral potassium salts are nausea, vomiting, flatulence, abdominal discomfort, and diarrhea. These symptoms are due to irritation of the gastrointestinal tract and are best managed by taking the dose with meals, or reducing the amount taken at one time. Skin rash has been reported rarely with potassium preparations.

Potassium-sparing diuretics, angiotensin converting enzyme inhibitors (see WARNINGS).