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Sporanox Overdose, Contraindications and Information - Itraconazole Capsules

OVERDOSE

Itraconazole is not removed by dialysis. In the event of accidental overdosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.

CONTRAINDICATIONS

Coadministration of terfenadine, astemizole or cisapride with Sporanox (itraconazole capsules) is contraindicated. (See BOXED WARNING, WARNINGS, and PRECAUTIONS.)

Concomitant administration of Sporanox with oral triazolam or with oral midazolam is contraindicated. (See PRECAUTIONS) .

Sporanox should not be administered for the treatment of onychomycosis to pregnant patients or to women contemplating pregnancy.

Sporanox is contraindicated in patients who have shown hypersensitivity to the drug or its excipients. There is no information regarding cross hypersensitivity between itraconazole and other azole antifungal agents. Caution should be used in prescribing Sporanox to patients with hypersensitivity to other azoles.

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