A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Imovax Side Effects, and Drug Interactions - Rabies Vaccine
Imovax Side Effects, and Drug Interactions - Rabies Vaccine
SIDE EFFECTS
Also See WARNINGS and CONTRAINDICATIONS
Sections for Additional Statements
Reactions after vaccination
with HDCV are less common
than with previously available vaccines. (10,12, 20) In
a study using five doses of HDCV
administered intramuscularly, local
reactions such as pain,
erythema and swelling
or itching at the injection
site were reported in about
25% of recipients; mild systemic
reactions such as headache,
nausea, abdominal
pain, muscle aches and
dizziness were reported
in about 20% of recipients. (9)
Clinical experience
with Mérieux Imovax Rabies l.D., Rabies Vaccine, has resulted
in a low incidence
of adverse reactions comparable to those following intramuscular
vaccination when
administered by the intradermal route except that a slight increase
in transient local
reactions has been observed following intradermal
vaccination, especially
when the vaccine is given in the forearm
rather than in the lateral
aspect of the upper arm.
Local reactions consist of redness, itching, mild pain
and minimal swelling at the site
of injection. Generalized reactions are uncommon.( 7) Mild local
or systemic reactions
can be treated with anti- inflammatory, antipyretic agents, e. g.,
aspirin and antihistamines.
Systemic allergic or anaphylactic reactions following primary
immunization have
been reported to be less than 1%. (14) If an anaphylactic reaction
should occur, epinephrine is indicated.
For “immune complex-like” reactions in persons receiving booster
doses of HDCV see WARNINGS.
Advice and assistance on the management of serious adverse reactions
in persons receiving primary or booster
rabies immunization
may be sought from the state
health department or CDC.( 9)
DRUG INTERACTIONS
Antimalarial drugs such
as chloroquine have been associated with a reduction in the antibody
response to Rabies
Vaccine administered by the intradermal route. Although it is apparent
that antimalarial
agents are not the sole factor responsible for the reduced antibody
response, it is recommended that persons on corticosteroids and
other immunosuppressive drugs receive Rabies Vaccine (3 doses/1.0
ml each) by the intramuscular
route until more definitive data is available. (16,17,18)
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