A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Vicodin Side Effects, and Drug Interactions - Hydrocodone and Acetaminophen
Vicodin Side Effects, and Drug Interactions - Hydrocodone and Acetaminophen
SIDE EFFECTS
The most frequently observed adverse reactions include lightheadedness,
dizziness, sedation, nausea, and vomiting. These effects seem to
be more prominent in ambulatory than in nonambulatory patients and
some of these adverse reactions may be alleviated if the patient
lies down.
Other adverse reactions include:
Central Nervous System: Drowsiness, mental
clouding, lethargy, impairment of mental
and physical performance,
anxiety, fear, dysphoria, psychic dependence, mood
changes.
Gastrointestinal System: The antiemetic
phenothiazines are useful in suppression
of the nausea and vomiting
which may occur; however, some phenothiazine derivatives seem to
be antianalgesic and to increase the amount of narcotic
required to produce pain
relief, while other phenothiazines reduce the amount of narcotic
required to produce a given level of analgesia. Prolonged administration
of hydrocodone bitartrate and acetaminophen
tablets may produce constipation.
Genitourinary System: Ureteral spasm, spasm
of vesical sphincters, and urinary retention
have been reported.
Respiratory Depression: Hydrocodone bitartrate may
produce dose-related respiratory depression
by acting directly on the brain
stem respiratory center. Hydrocodone also affects the center
that controls respiratory rhythm and may produce irregular and periodic
breathing.
If significant
respiratory depression
occurs, it may be antagonized by the use of naloxone hydrochloride.
Apply other supportive measures when indicated.
Dermatological: Skin rash, pruritus.
DRUG ABUSE AND DEPENDENCE
Hydrocodone bitartrate and acetaminophen
tablets are subject
to the Federal Controlled Substance Act (Schedule III).
Psychic dependence, physical
dependence, and tolerance
may develop upon repeated administration
of narcotics; therefore, hydrocodone bitartrate and acetaminophen
tablets should be prescribed and administered with caution. However,
psychic dependence
is unlikely to develop when hydrocodone bitartrate and acetaminophen
tablets are used for a short time
for the treatment
of pain.
Physical dependence, the condition
in which continued administration of the drug
is required to prevent the appearance
of a withdrawal syndrome,
assumes clinically significant
proportions only after several weeks of continued narcotic
use, although some mild degree
of physical dependence
may develop after a few days of narcotic
therapy. Tolerance, in which increasingly large doses are required
in order to produce the
same degree of analgesia,
is manifested initially by a shortened duration
of analgesic effect
and subsequently by decreases in the intensity of analgesia. The
rate of development of
tolerance varies among
patients.
DRUG INTERACTIONS
Patients receiving other narcotic
analgesics, antipsychotics, antianxiety agents, or other CNS
depressants (including alcohol) concomitantly with hydrocodone and
acetaminophen
tablets may exhibit an additive
CNS depression. When combined
therapy is contemplated, the dose
of one or both agents should be reduced.
The use of MAO inhibitors
or tricyclic antidepressants with hydrocodone preparations may increase
the effect of either
the antidepressant
or hydrocodone.
The concurrent use of anticholinergics with hydrocodone may produce
paralytic ileus.
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