A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Apresoline Side Effects, and Drug Interactions - Hydralazine
Apresoline Side Effects, and Drug Interactions - Hydralazine
SIDE EFFECTS
Adverse reactions with hydralazine are usually reversible
when dosage is reduced. However, in some cases it may be necessary
to discontinue the drug. The following adverse reactions have been
observed, but there has not been enough systematic
collection of data to support
an estimate of their frequency.
- Common: Headache, anorexia,
nausea, vomiting,
diarrhea, palpitations,
tachycardia, angina
pectoris
- Less Frequent: Digestive: constipation,
paralytic ileus.
- Cardiovascular: hypotension,
paradoxical pressor
response, edema.
- Respiratory: dyspnea
- Neurologic: peripheral
neuritis, evidenced
by paresthesia,
numbness, and tingling, dizziness,
tremors, muscle cramps,
psychohc reactions characterized by depression,
disorientation, or anxiety.
- Genitourinary: difficulty in urination
- Hematologic: blood
dyscrasias, consisting of reduction
in hemoglobin and red
cell count, leukopenia,
agranulocytosis,
purpura, lymphadenopathy,
splenomegaly
- Hypersensitivity Reactions: rash,
urticaria, pruritis,
fever, chills, arthralgia,
eosinophilia,
and rarely, hepatitis.
- Other: nasal
congestion, flushing, lacrimation,
conjunctivitis.
DRUG INTERACTIONS
MAO inhibitors should be used with caution in patients receiving
hydralazine.
When other potent parental
antihypertensive
drugs, such as diazoxide,
are used in combination with hydralazine, patients should be continuously
observed for several hours for any excessive fall
in blood pressure. Profound
hypotensive episodes may occur when diazoxide
infection and hydralazine
are used concomitantly.
Beta-blockers (metoprolol, propranolol) serum concentrations and pharmacologic effects may be increased. Monitor cardiovascular status.
Propranolol increases hydralazine's serum concentrations. Acebutolol, atenolol, and nadolol (low hepatic clearance or no first-pass metabolism) are unlikely to be affected.
NSAIDs may decrease the hemodynamic effects of hydralazine; avoid use if possible or closely monitor cardiovascular status” at the end of drug interactions
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