A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Hemabate Side Effects, and Drug Interactions - Carboprost tromethamine
Hemabate Side Effects, and Drug Interactions - Carboprost tromethamine
SIDE EFFECTS
The adverse effects of HEMABATE Sterile Solution are generally
transient and reversible when therapy ends. The most frequent adverse reactions
observed are related to its contractile effect on smooth muscle.
In patients studied, approximately two-thirds experienced vomiting
and diarrhea, approximately one-third had nausea, one-eighth had a temperature
increase greater than 2° F, and one-fourteenth experienced flushing.
The pretreatment or concurrent administration of antiemetic
and antidiarrheal drugs decreases considerably the very high incidence of gastrointestinal
effects common with all prostaglandins used for abortion. Their use should be
considered an integral part of the management of patients undergoing abortion
with HEMABATE.
Of those patients experiencing a temperature elevation, approximately
one-sixteenth had a clinical diagnosis of endometritis. The remaining temperature
elevations returned to normal within several hours after the last injection.
Adverse effects observed during the use of HEMABATE for abortion
and for hemorrhage, not all of which are clearly drug related, in decreasing
order of frequency include:
|
Vomiting
|
Nervousness
|
|
Diarrhea
|
Nosebleed
|
|
Nausea
|
Sleep disorders
|
|
Flushing or hot flashes
|
Dyspnea
|
|
Chills or shivering
|
Tightness in chest
|
|
Coughing
|
Wheezing
|
|
Headaches
|
Posterior cervical
|
|
Endometritis
|
perforation
|
|
Hiccough
|
Weakness
|
|
Dysmenorrhea-like
|
Diaphoresis
|
|
pain
|
Dizziness
|
|
Paresthesia
|
Blurred vision
|
|
Backache
|
Epigastric pain
|
|
Muscular pain
|
Excessive thirst
|
|
Breast tenderness
|
Twitching eyelids
|
|
Eye pain
|
Gagging, retching
|
|
Drowsiness
|
Dry throat
|
|
Dystonia
|
Sensation of choking
|
|
Asthma
|
Thyroid storm
|
|
Injection site pain
|
Syncope
|
|
Tinnitus
|
Palpitations
|
|
Vertigo
|
Rash
|
|
Vaso-vagal syndrome
|
Upper respiratory
|
|
Dryness of mouth
|
infection
|
|
Hyperventilation
|
Leg cramps
|
|
Respiratory distress
|
Perforated uterus
|
|
Hematemesis
|
Anxiety
|
|
Taste alterations
|
Chest pain
|
|
Urinary tract infection
|
Retained placental
|
|
Septic shock
|
fragment
|
|
Torticollis
|
Shortness of breath
|
|
Lethargy
|
Fullness of throat
|
|
Hypertension
|
Uterine sacculation
|
|
Tachycardia
|
Faintness, light-
|
|
Pulmonary edema
|
headedness
|
|
Endometritis from
|
Uterine rupture
|
|
IUCD
|
|
The most common complications when HEMABATE was utilized for
abortion requiring additional treatment after discharge from the hospital were
endometritis, retained placental fragments, and excessive uterine bleeding,
occurring in about one in every 50 patients.
DRUG INTERACTIONS
HEMABATE may augment the activity of other oxytocic agents. Concomitant use with other oxytocic agents is not recommended.
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