A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Hydrodiuril Side Effects, and Drug Interactions - Hydrochlorothiazide
Hydrodiuril Side Effects, and Drug Interactions - Hydrochlorothiazide
SIDE EFFECTS
The following adverse reactions have been reported and
within each category, are listed in order
of decreasing severity.
Body as a Whole: Weakness.
Cardiovascular: Hypotension including orthostatic
hypotension (may be aggravated by alcohol,
barbiturates, narcotics or antihypertensive drugs).
Digestive: Pancreatitis, jaundice
(intrahepatic cholestatic jaundice), diarrhea, vomiting,
sialadenitis, cramping, constipation,
gastric irritation,
nausea, anorexia.
Hematologic: Aplastic anemia, agranulocytosis, leukopenia,
hemolytic anemia,
thrombocytopenia.
Hypersensitivity: Anaphylactic reactions, necrotizing
angiitis (vasculitis and cutaneous
vasculitis), respiratory
distress including
pneumonitis and pulmonary
edema, photosensitivity,
fever, urticaria,
rash, purpura.
Metabolic: Electrolyte imbalance
(see PRECAUTIONS), hyperglycemia,
glycosuria, hyperuricemia.
Musculoskeletal: Muscle spasm.
Nervous System/Psychiatric: Vertigo, paresthesias, dizziness,
headache, restlessness.
Renal: Renal failure, renal
dysfunction, interstitial
nephritis. (See WARNINGS.)
Skin: Erythema multiforme including Stevens-Johnson syndrome,
exfoliative dermatitis
including toxic epidermal
necrolysis, alopecia.
Special Senses: Transient blurred vision, xanthopsia.
Urogenital: Impotence.
Whenever adverse reactions are moderate or severe, thiazide dosage
should be reduced or therapy
withdrawn.
DRUG INTERACTIONS
When given concurrently the following drugs may interact with thiazide
diuretics.
Alcohol, barbiturates, or narcotics: potentiation
of orthostatic hypotension may occur.
Antidiabetic drugs: (oral agents and insulin) - dosage
adjustment of the antidiabetic
drug may be required.
Other antihypertensive
drugs: additive
effect or potentiation.
Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide
is impaired in the presence of anionic exchange
resins. Single doses of either cholestyramine or colestipol resins
bind the hydrochlorothiazide
and reduce its absorption
from the gastrointestinal
tract by up to 85 and
43 percent, respectively.
Corticosteroids, ACTH: intensified electrolyte
depletion, particularly hypokalemia.
Pressor amines (e.g., norepinephrine): possible
decreased response to pressor
amines but not sufficient to preclude their use.
Skeletal muscle
relaxants, nondepolarizing (e.g., tubocurarine): possible
increased responsiveness to the muscle
relaxant.
Lithium: generally should not be given with diuretics.
Diuretic agents reduce
the renal clearance
of lithium and add
a high risk of lithium
toxicity. Refer to the package insert for lithium
preparations before use of such
preparations with Hydrochlorothiazide.
Non-steroidal Anti-inflammatory Drugs: In
some patients, the administration of a non-steroidal anti-inflammatory
agent can reduce
the diuretic, natriuretic, and antihypertensive
effects of loop, potassium-sparing and thiazide diuretics. Therefore,
when Hydrochlorothiazide and non-steroidal anti-inflammatory agents
are used concomitantly, the patient
should be observed closely to determine if the desired effect
of the diuretic is
obtained.
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