A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Raxar Overdose, Contraindications and Information - Grepafloxacin
Raxar Overdose, Contraindications and Information - Grepafloxacin
OVERDOSE
In the event of acute
overdosage, the stomach
should be emptied by inducing vomiting or by gastric
lavage. The patient
should be carefully observed and given supportive treatment. As
with other quinolones, adequate hydration and electrolyte
balance must be maintained.
Due to the possibility of prolongation of the QTc interval
and complications including arrhythmias, ECG monitoring is recommended
after overdosage with RAXAR. It is not known if grepafloxacin can
be efficiently removed by hemodialysis
or peritoneal dialysis.
At oral doses of 4500
mg/kg (14,400 mg/m2) in mice and 3000 mg/kg (21,000 mg/m2)
in rats significant
increases in mortality were noted. These doses were approximately
equivalent to 39
(mice) and 57 rats times the human
dose on a mg/m2
basis.
CONTRAINDICATIONS
RAXAR Tablets are contraindicated in persons with a history
of hypersensitivity to grepafloxacin or other members of the quinolone
class of antimicrobial
agents. RAXAR Tablets are contraindicated in patients with hepatic
failure. Because prolongation of the QTc interval
has been observed in healthy volunteers receiving RAXAR, RAXAR Tablets
are contraindicated in patients with known QTc prolongation.
RAXAR Tablets are also contraindicated in patients being treated
concomitantly with medications known to produce an increase in the
QTc interval
and/or torsade de pointes (e.g., terfenadine) unless appropriate
cardiac monitoring can
be assured (e.g., in hospitalized patients) (see WARNINGS
).
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