A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Glucotrol Online, Description, Chemistry, Ingredients - Glipizide
Glucotrol Online, Description, Chemistry, Ingredients - Glipizide
DESCRIPTION
Immediate and Extended Release Tablets
Glipizide is an oral blood-glucose-lowering
drug of the sulfonylurea class.
The chemical abstracts name
of glipizide is 1-cyclohexyl-3-[[p-(2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea.
The molecular formula is C21H27N5O4S;
the molecular weight is 445.55.
Glipizide is a whitish, odorless powder
with a pKa of 5.9. It is insoluble in water
and alcohols, but soluble
in 0.1 N NaOH; it is freely soluble in dimethylformamide.
Immediate Release Tablets: Each immediate
release tablet, for oral
administration contains
glipizide, 5 mg or 10 mg and the following inactive ingredients: corn
starch, anhydrous lactose,
microcrystalline cellulose, colloidal silicon
dioxide and stearic acid.
Extended Release Tablets: Inert ingredients in the formulations
are: polyethylene oxide,
hydroxypropyl methylcellulose, magnesium
stearate, sodium chloride, red
ferric oxide, cellulose
acetate, polyethylene
glycol, opadry white and black
ink.
Extended Release Tablets
Glucotrol XL extended release
tablets are similar in appearance
to a conventional tablet. It consists, however, of an osmotically active
drug core surrounded by a semipermeable
membrane. The core itself is
divided into two layers: an "active" layer
containing the drug, and a "push" layer
containing pharmacologically insert (but osmotically active) components.
The membrane surrounding
the tablet is permeable
to water but not to drug or osmotic
excipients. As water from the
gastrointestinal tract enters the tablet
pressure increases in the
osmotic layer and "pushes"
against the drug layer, resulting
in the release of through
a small, laser-drilled orifice in the membrane
on the drug side
of the tablet.
The Glucotrol XL extended release
tablet is designed to provide
a controlled rate of delivery of glipizide. into the gastrointestinal
lumen which is independent of
pH or gastrointestinal
motility. The function of
the Glucotrol XL extended release
tablet depends upon the existence
of an osmotic gradient between the contents of the bi-layer core
and fluid in the GI
tract. Drug delivery is essentially constant
as long as the osmotic gradient
remains constant, and then gradually falls to zero. The biologically inert
components of the tablet remain
intact during drug GI
transit and are eliminated in the feces
as an insoluble shell.
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