A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lasix Side Effects, and Drug Interactions - Furosemide
Lasix Side Effects, and Drug Interactions - Furosemide
SIDE EFFECTS
Adverse reactions are categorized below by organ
system and listed by
decreasing severity:
Gastrointestinal System Reactions
- 1. Pancreatitis.
- 2. Jaundice (intrahepatic cholestatic juandice).
- 3. Anorexia.
- 4. Oral and gastric
irritation.
- 5. Cramping.
- 6. Diarrhea.
- 7. Constipation.
- 8. Nausea.
- 9. Vomiting.
Systemic Hypersensitivity Reactions
- 1. Systemic vasculitis.
- 2. Interstitial nephritis.
- 3. Necrotizing angiitis.
Central Nervous System Reactions
- 1. Tinnitus and hearing
loss.
- 2. Paresthesias.
- 3. Vertigo.
- 4. Dizziness.
- 5. Headache.
- 6. Blurred vision.
- 7. Xanthopsia.
Hematologic Reactions
- 1. Aplastic anemia
(rare).
- 2. Thrombocytopenia.
- 3. Agranulocytosis (rare).
- 4. Hemolytic anemia.
- 5. Leukopenia.
- 6. Anemia.
Dermatologic-Hypersensitivity Reactions
- 1. Exfoliative dermatitis.
- 2. Erythema multiforme.
- 3. Purpura.
- 4. Photosensitivity.
- 5. Urticaria.
- 6. Rash.
- 7. Pruritus.
Cardiovascular Reaction: Orthostatic hypotension
may occur and be aggravated by alcohol, barbiturates
or narcotics.
Other Reactions
- 1. Hyperglycemia.
- 2. Glycosuria.
- 3. Hyperuricemia.
- 4. Muscle spasm.
- 5. Weaknesses.
- 6. Restlessness.
- 7. Urinary bladder
spasm.
- 8. Thrombophlebitis.
- 9. Fever.
Whenever adverse reactions are moderate or severe, furosemide
dosage should be reduced or therapy withdrawn.
DRUG INTERACTIONS
Furosemide may increase the ototoxic
potential of aminoglycoside
antibiotics, especially in the presence of impaired renal
function. Except in life-threatening situations, avoid this combination.
Furosemide should not be used concomitantly with ethacrynic acid
because of the possibility of ototoxicity. Patients receiving high
doses of salicylates concomitantly with furosemide, as in rheumatic
disease, may experience salicylate toxicity at lower doses because
of competitive renal excretory
sites.
Furosemide has a tendency to antagonize the skeletal
muscle relaxing effect
of tubocurarine and may potentiate
the action of succinylcholine.
Lithium generally should not be given with diuretics because they
reduce lithium's renal
clearance and add
a high risk of lithium
toxicity.
Furosemide may add to or
potentiate the therapeutic
effect of other antihypertensive
drugs. Potentiation occurs with ganglionic
or peripheral adrenergic blocking
drugs.
Furosemide may decrease arterial
responsiveness to norepinephrine. However, norepinephrine may still
be used effectively.
Tablets
Simultaneous administration
of sucralfate and
furosemide tablets
may reduce the natriuretic
and antihypertensive
effects of furosemide. Patients receiving both drugs should be observed
closely to determine if the desired diuretic and/or antihypertensive
effect of furosemide
is achieved. The intake of furosemide
and sucralfate should
be separated by at least two hours.
Tablets, Injection, and Oral Solution
One study in six subjects demonstrated that the combination of
furosemide and acetylsalicylic acid
temporarily reduced creatinine
clearance in patients
with chronic renal
insufficiency. There are case
reports of patients who developed increased BUN, serum
creatinine and serum
potassium levels,
and weight gain when furosemide
was used in conjunction with NSAIDs.
Literature reports indicate that coadministration
of indomethacin
may reduce the natriuretic
and antihypertensive
effects of furosemide
in some patients by inhibiting prostaglandin
synthesis. Indomethacin may also affect plasma renin
levels, aldosterone
excretion, and renin profile
evaluation. Patients receiving both indomethacin
and furosemide should
be observed closely to determine if the desired diuretic
and/or antihypertensive
effect of furosemide
is achieved.
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