A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Flonase Online, Description, Chemistry, Ingredients - Fluticasone propionate
Flonase Online, Description, Chemistry, Ingredients - Fluticasone propionate
DESCRIPTION
Fluticasone propionate, the active component of FLONASE
Nasal Spray, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6a,9-difluoro-11ß-17-dihydroxy-16a-methyl-3-oxoandrosta- 1,4-diene-17ß-carbothioate,
17-propionate and the following chemical structure:
Fluticasone propionate is a white to off-white powder with
a molecular weight of 500.6, and the empirical formula is C25H31F3O5S.
It is practically insoluble in water, freely soluble in dimethyl sulfoxide and
dimethylformamide, and slightly soluble in methanol and 95% ethanol.
FLONASE Nasal Spray, 50 mcg is an aqueous suspension of microfine
fluticasone propionate for topical administration to the nasal mucosa by means
of a metering, atomizing spray pump. FLONASE Nasal Spray also contains microcrystalline
cellulose and carboxymethylcellulose sodium, dextrose, 0.02% w/w benzalkonium
chloride, polysorbate 80, and 0.25% w/w phenylethyl alcohol, and has a pH between
5 and 7.
It is necessary to prime the pump before first use or after
a period of non-use (1 week or more). After initial priming (6 actuations),
each actuation delivers 50 mcg of fluticasone propionate in 100 mg of formulation
through the nasal adapter. Each 16-g bottle of FLONASE Nasal Spray provides
120 metered sprays. After 120 metered sprays, the amount of fluticasone propionate
delivered per actuation may not be consistent and the unit should be discarded.
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