Fdg Online, Description, Chemistry, Ingredients - Fluorodeoxyglucose F18 Inj

Fdg Online, Description, Chemistry, Ingredients - Fluorodeoxyglucose F18 Inj

Fluorodeoxyglucose F18 Injection [18F] FDG

Diagnostic - For Intravenous Administration

DESCRIPTION

Fluorodeoxyglucose F18, (2-deoxy-2[18F]fluoro-D-glucose), Injection is an intravenous, diagnostic radiopharmaceutical for Positron Emission Tomography (PET).

[18F]FDG is supplied in isotonic saline as a sterile, non-pyrogenic, clear, colorless solution. The pH of [18F]FDG is 5.5 - 7.5

Fluorodeoxyglucose F18, (2-deoxy-2-[18F]fluoro-D-glucose), may be abbreviated [18F]FDG. The structural formula for [18F]FDG is the following:

Each vial contains at the end of bombardment (EOB) 68-1071 mCi of 2-deoxy-2-[18F]fluoro-D-glucose with a specific activity of no less than 11 Ci/mmol. Each mL of [18F]FDG contains at EOB 68-357mCi/mL of 2-deoxy-2-[18F]fluoro-D-glucose and 0-9 mg of sodium chloride.

[18F]FDG is produced in an automated radiochemical synthesis unit from cyclotron produced Fluorine F18. Fluorine F 18 is produced by proton bombardment of enriched [ 18O]water and is bound to1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl- b -D-mannopyranose (mannose triflate) under stereo specific S N2 reaction conditions. This renders no carrier added Fluorodeoxyglucose F 18. The pH is adjusted by passage through cation retardation resin.

Physical Characteristics

Fluorine F 18 decays by positron ( b +) emission and has a half life of 109.8 minutes. The principal photons useful for diagnostic imaging are the 511 keV gamma photons, resulting from the interaction of the emitted positron with an electron (Table1).

Table 1. Principal Emission Data for Fluorine F 18

*Produced by positron annihilation

From: Kocher, D.C. "Radioactive Decay Tables" DOE/TIC-11026, 89(1981).

External Radiation

The specific gamma ray constant for Fluorine F 18 is 6.0 R/hr/mCi(0.3 Gy/hr/kBq) at 1cm. The half-value layer (HVL) for the 511keV photons is 4.1 mm lead (Pb). A range of values for the attenuation of radiation results from the interposition of various thickness of Pb. The range of attenuation coefficients for this radionuclide is shown in Table 2. For example the interposition of an 8.3 mm thickness of Pb, with a coefficient of attenuation of 0.25, will decrease the external radiation by 75%.

Table 2. Radiation Attenuation of 511 keV Photons by Lead (Pb) Shielding

For use in correcting for physical decay of this radionuclide, the fractions remaining at selected intervals after calibration are shown in Table 3.