A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Flolan Online, Description, Chemistry, Ingredients - Epoprostenol sodium
Flolan Online, Description, Chemistry, Ingredients - Epoprostenol sodium
FLOLAN®
(epoprostenol sodium) for Injection
DESCRIPTION
FLOLAN (epoprostenol sodium) for Injection is a sterile sodium
salt formulated for intravenous (IV) administration. Each vial of FLOLAN contains
epoprostenol sodium equivalent to either 0.5 mg (500,000 ng) or 1.5 mg (1,500,000
ng) epoprostenol, 3.76 mg glycine, 2.93 mg sodium chloride, and 50 mg mannitol.
Sodium hydroxide may have been added to adjust pH.
Epoprostenol (PGI2, PGX, prostacyclin), a metabolite
of arachidonic acid, is a naturally occurring prostaglandin with potent vasodilatory
activity and inhibitory activity of platelet aggregation.
Epoprostenol is (5Z,9a ,11a
,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-l-oic acid.
Epoprostenol sodium has a molecular weight of 374.45 and a
molecular formula of C20H31NaO3.
FLOLAN is a white to off-white powder that must be reconstituted
with STERILE DILUENT for FLOLAN STERILE DILUENT for FLOLAN is supplied in 50-mL
glass vials containing 94 mg glycine, 73.5 mg sodium chloride, sodium hyrdroxide
(added to adjust pH), and Water for Injection, USP.
The reconstituted solution of FLOLAN has a pH of 10.2 to 10.8
and is increasingly unstable at a lower pH.
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