A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Pondimin Side Effects, and Drug Interactions - Fenfluramine
Pondimin Side Effects, and Drug Interactions - Fenfluramine
SIDE EFFECTS
The most common adverse reactions of fenfluramine are drowsiness,
diarrhea, and dry mouth. Less frequent adverse reactions reported
in association with fenfluramine are:
Central nervous
system: Dizziness; confusion; incoordination; headache; elevated
mood; depression; anxiety,
nervousness, or tension; insomnia; weakness
or fatigue; increased or decreased libido; agitation, dysarthria.
Gastrointestinal: Constipation; abdominal
pain; nausea.
Autonomic: Sweating; chills; blurred vision.
Genitourinary: Dysuria; urinary
frequency.
Cardiovascular: Palpitation; hypotension; hypertension;
fainting; pulmonary hypertension.
Skin: Rash; urticaria; burning sensation.
Miscellaneous: Eye irritation; myalgia; fever; chest
pain; bad taste.
Drug Abuse and Dependence
Pondimin (fenfluramine hydrochloride) is a controlled substance
in Schedule IV. Fenfluramine is related chemically to the amphetamines,
although it differs somewhat pharmacologically. The amphetamines
and related stimulant drugs have been extensively abused and can
produce tolerance
and severe psychological dependence,
as well as other adverse organic
and mental changes. In
this regard, there has been a report
of abuse of fenfluramine
by subjects with a history
of abuse of other drugs.
Abuse of 80 to 400 milligrams of the drug
has been reported to be associated with euphoria,
derealization, and perceptual changes. Fenfluramine did not produce
signs of dependence in animals and appears to produce sedation
more often than CNS stimulation
at therapeutic doses.
Its abuse potential
appears qualitatively different from that of amphetamines. The possibility
that fenfluramine may induce dependence should be kept in mind
when evaluating the desirability of including the drug
in the weight reduction
programs of individual patients.
DRUG INTERACTIONS
Fenfluramine may increase slightly the effect
of antihypertensive
drugs, e.g., guanethidine, methyldopa, reserpine.
Other CNS depressant
drugs should be used with caution in patients taking fenfluramine,
since the effects may be additive.
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