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Deconamine Side Effects, and Drug Interactions - Guaifenesin; Hydrocodone; Pseudoephedrine
SIDE EFFECTS
Gastrointestinal upset, nausea, drowsiness and constipation. A slight elevation in serum transaminase levels has been noted.
Individuals hyperreactive to pseudoephedrine may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness or nausea. Sympathomimetic drugs have been associated with certain untoward reactions including fear, anxiety, tenseness, restlessness, tremor, weakness, pallor, respiratory difficulty, dysuria, insomnia, hallucinations, convulsions, CNS depression, arrhythmias, and cardiovascular collapse with hypotension. Patient idiosyncrasy to adrenergic agents may be manifested by insomnia, dizziness, weakness, tremor or arrhythmias.
Drug Abuse and Dependence
Controlled Substance: Hydrocodone in this combination elixir is controlled by the Drug Enforcement Administration. This combination elixir is a Schedule III controlled substance.
Abuse: Hydrocodone is a narcotic drug related to codeine with similar abuse potential.
Dependence: Hydrocodone can produce drug dependence of the morphine type. Psychic dependence, physical dependence and tolerance may develop if dosage recommendations are greatly exceeded over a prolonged period of time.
DRUG INTERACTIONS
Hydrocodone may potentiate the effects of other narcotics, general anesthetics, tranquilizers, sedatives and hypnotics, tricyclic antidepressants, MAO inhibitors, alcohol, and other CNS depressants. Beta-adrenergic blockers and MAO inhibitors potentiate the sympathomimetic effects of pseudoephedrine. Sympathomimetics may reduce the antihypertensive effects of methyldopa, mecamylamine, reserpine and veratrum alkaloids.
DO NOT TAKE THIS MEDICINE if you are also taking furazolidone or a monoamine oxidase inhibitor (MAOI). ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking bromocriptine, guanadrel, guanethidine, or medicine to alkalinize the urine.
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