A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Xigris Online, Description, Chemistry, Ingredients - Drotrecogin alfa
Xigris Online, Description, Chemistry, Ingredients - Drotrecogin alfa
XigrisÔ
Drotrecogin alfa (activated)
DESCRIPTION
Xigrisä (drotrecogin alfa (activated))
is a recombinant form of human Activated Protein C. An established human cell
line possessing the complementary DNA for the inactive human Protein C zymogen
secretes the protein into the fermentation medium. Fermentation is carried out
in a nutrient medium containing the antibiotic geneticin sulfate. Geneticin
sulfate is not detectable in the final product. Human Protein C is enzymatically
activated by cleavage with thrombin and subsequently purified.
Drotrecogin alfa (activated) is a serine protease with the
same amino acid sequence as human plasma-derived Activated Protein C. Drotrecogin
alfa (activated) is a glycoprotein of approximately 55 kilodalton molecular
weight, consisting of a heavy chain and a light chain linked by a disulfide
bond. Drotrecogin alfa (activated) and human plasma-derived Activated Protein
C have the same sites of glycosylation, although some differences in the glycosylation
structures exist.
Xigris is supplied as a sterile, lyophilized, white to off-white
powder for intravenous infusion. The 5 and 20 mg vials of Xigris contain 5.3
mg and 20.8 mg of drotrecogin alfa (activated), respectively. The 5 and 20 mg
vials of Xigris also contain 40.3 and 158.1 mg of sodium chloride, 10.9 and
42.9 mg of sodium citrate, and 31.8 and 124.9 mg of sucrose, respectively.
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