A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Doryx Side Effects, and Drug Interactions - Doxycycline
Doryx Side Effects, and Drug Interactions - Doxycycline
SIDE EFFECTS
Due to oral doxycycline's
virtually complete absorption,
side effects of the lower
bowel, particularly diarrhea,
have been infrequent. The following adverse reactions have been
observed in patients receiving tetracyclines:
Gastrointestinal: anorexia,
nausea, vomiting,
diarrhea, glossitis,
dysphagia, enterocolitis,
and inflammatory
lesions (with monilial overgrowth) in the anogenital
region. Hepatotoxicity has been reported rarely. These reactions
have been caused by both the oral
and parenteral administration
of tetracyclines. Rare instances of esophagitis
and esophageal ulcerations
have been reported in patients receiving capsule
and tablet forms of the
drugs in the tetracycline
class. Most of these patients took medications immediately before
going to body (See DOSAGE
AND ADMINISTRATION.)
Skin: maculopapular
and erythematous rashes. Exfoliative dermatitis has been reported
but is uncommon. Photosensitivity is discussed above. (See WARNINGS.)
Renal toxicity: rise in BUN
has been reported and is apparently dose related. (See WARNINGS.)
Hypersensitivity reactions: urticaria,
angioneurotic edema, anaphylaxis,
anaphylactoid purpura,
serum sickness, pericarditis,
and exacerbation
of systemic lupus erythematosus.
Blood: Hemolytic anemia,
thrombocytopenia,
neutropenia, and
eosinophilia have been reported.
Other: bulging fontanels in infants and intracranial
hypertension in adults. See PRECAUTIONS,
General.
When given over prolonged periods, tetracyclines have been reported
to produce brown-black microscopic discoloration of the thyroid
gland. No abnormalities of thyroid
function studies are
known to occur.
DRUG INTERACTIONS
Because tetracyclines have been shown to depress plasma
prothrombin activity, patients who are on anticoagulant
therapy may require
downward adjustment of their anticoagulant
dosage.
Since bacteriostatic
drugs may interfere with the bactericidal
action of penicillin, it is advisable to avoid giving tetracyclines
in conjunction with penicillin.
Absorption of tetracyclines is impaired by antacids containing
aluminum, calcium, or magnesium,
and iron-containing preparations.
Absorption of tetracycline
is impaired by bismuth
subsalicylate.
Barbiturates, carbamazepine, and phenytoin
decrease the half-life
of doxycycline.
The concurrent use of tetracycline
and Penthrane (methoxyflurane) has been reported to result in fatal
renal toxicity.
Concurrent use of tetracycline
may render oral contraceptives
less effective.
top
