A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cardura Overdose, Contraindications and Information - Doxazosin Mesylate
Cardura Overdose, Contraindications and Information - Doxazosin Mesylate
OVERDOSE
Experience with doxazosin mesylate overdosage is limited. Two adolescents
who each intentionally ingested 40 mg
doxazosin mesylate with diclofenac or paracetamol, were treated
with gastric lavage
with activated charcoal
and made full recoveries. A two-year-old child
who accidentally ingested 4 mg doxazosin mesylate was treated with
gastric lavage
and remained normotensive during the five-hour emergency room
observation period. A six-month-old child accidentally received
a crushed 1 mg tablet
of doxazosin mesylate and was reported to have been drowsy. A 32-year-old
female with chronic
renal failure, epilepsy
and depression intentionally
ingested 60 mg doxazosin
mesylate (blood level 0.9 mg/ml; normal
values in hypertensives=0.02 mcg/ml); death
was attributed to a grand mal
seizure resulting from
hypotension. A 39-year-old female
who ingested 70 mg doxazosin
mesylate, alcohol and
Dalmane (flurazepam) developed hypotension which responded to fluid
therapy.
The oral LD50
of doxazosin is greater than 1000 mg/kg in mice and rats. The most
likely manifestation
of overdosage would be hypotension, for which the usual treatment
would be intravenous
infusion of fluid. As doxazosin
is highly protein bound,
dialysis would not
be indicated.
CONTRAINDICATIONS
Doxazosin mesylate is contraindicated in patients with a known
sensitivity to quinazolines (e.g., prazosin, terazosin).
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