A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Antabuse Pharmacology, Pharmacokinetics, Studies, Metabolism - Disulfiram
Antabuse Pharmacology, Pharmacokinetics, Studies, Metabolism - Disulfiram
CLINICAL PHARMACOLOGY
Disuifiram produces a sensitivity
to alcohol which results
in a highly unpleasant reaction
when the patient under
treatment ingests
even small amounts of alcohol.
Disulfiram blocks the oxidation
of alcohol at the acetaldehyde
stage During alcohol
metabolism following
disulfiram intake,
the concentration of acetaldehyde
occurring in the blood
may be 5 to 10 times higher than that found during metabolism
of the same amount of alcohol
alone.
Accumulation of acetaldehyde
in the blood produces
a complex of highly
unpleasant symptoms referred to hereinafter as the disulfiram-alcohol
reaction. This reaction,
which is proportional to the dosage
of both disulfiram
and alcohol, will persist
as long as alcohol is
being metabolized. Disulfi ram does not appear to influence the
rate of alcohol
elimination from
the body.
Disulfiram is absorbed slowly from the gastrointestinal
tract and is eliminated
slowly from the body. One (or even two) weeks after a patient has
taken his last dose of
disulfiram. ingestion
of alcohol may produce
unpleasant symptoms.
Prolonged administration
of disulfiram does
not produce tolerance; the longer a patient
remains on therapy. the more exquisitely sensitive
he becomes to alcohol.
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