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Benadryl Pharmacology, Pharmacokinetics, Studies, Metabolism - Diphenhydramine

CLINICAL PHARMACOLOGY

Diphenhydramine HCl is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

Diphenhydramine is widely distributed throughout the body, including the CNS.

Capsules and Elixir

A single oral dose of diphenhydramine HCl is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of diphenhydramine HCl is from four to six hours. Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

Injection

Diphenhydramine HCl in the injectable form has a rapid onset of action. Detailed information on the pharmacokinetics of diphenhydramine HCl injection is not available.

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