Lanoxin Online, Description, Chemistry, Ingredients - Digoxin

Lanoxin Online, Description, Chemistry, Ingredients - Digoxin

DESCRIPTION

Digoxin is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term "digitalis" is used to designate the whole group of glycosides. The glycosides are composed of two portions: a sugar and a cardenolide (hence "glycosides").

Digoxin is described chemically as (3b, 5b, 12b)-3-[(O-2,6-dideoxy-b-D-ribo- hexopyranosyl-(1“4)-O-2,6-dideoxy-b- D-ribo-hexopyranosyl-(1“4)-2,6-dideoxy-b-D- ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide. Its molecular formula is C₄₁H₆₄O₁₄, and its molecular weight is 780.95, and its structural formula is:

Digoxin exists as odorless white crystals that melt with decomposition above 230°C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.

Tablets: Lanoxin is supplied as 125-mcg (0.125-mg) or 250-mcg (0.25-mg) tablets for oral administration. Each tablet contains the labeled amount of digoxin and the following inactive ingredients: corn and potato starches, lactose, and magnesium stearate. In addition, the dyes used in the 125-mcg (0.125-mg) tablets are D&C yellow no. 10 and FD&C yellow no. 6.

Capsules: Lanoxicaps is a stable solution of digoxin enclosed within a soft gelatin capsule for oral use. Each capsule contains the labeled amount of digoxin dissolved in a solvent comprised of polyethylene glycol 400, 8% ethyl alcohol, propylene glycol, and purified water. Inactive ingredients in the Lanoxin capsule shell include FD&C red no. 40 (0.05-mg capsule), D&C yellow no. 10 (0.1-mg and 0.2-mg capsules), FD&C blue no. 1 (0.2 mg capsule), gelatin, glycerin, methylparaben and propylparaben (added as preservatives), purified water and sorbitol. Capsules are printed with edible ink.

Pediatric Elixir: Lanoxin elixir pediatric is a stable solution of digoxin specially formulated for oral use in infants and children. Each ml contains 50 mg (0.05 mg) digoxin. The lime-flavored elixir contains the inactive ingredients alcohol 10%, methylparaben 0.1% (added as a preservative), citric acid, D&C green no. 5 and yellow no. 10, flavor, propylene glycol, sodium phosphate, and sucrose. Each package is supplied with a specially calibrated dropper to facilitate the administration of accurate dosage even in premature infants. Starting at 0.2 ml, this 1-ml dropper is marked in divisions of 0.1 ml, each corresponding to 5 mg (0.005 mg) digoxin.

Lanoxin Injection (Including Pediatric): Lanoxin injection is a sterile solution of digoxin for intravenous injection. The vehicle contains 40% propylene glycol and 10% alcohol. The injection is buffered to a pH of 6.8 to 7.2 with 0.17% sodium phosphate and 0.08% anhydrous citric acid. For Adult Injection: Each 2-ml ampul contains 500 mg (0.5 mg) digoxin (250 mg [0.25 mg] per ml). For Pediatric Injection: Each 1-ml ampul contains 100 mg (0.1 mg) digoxin. Dilution is not required.